E-ISSN 3041-4199
 
2025, Vol: 2, Issue: 1
2 / 1Current Issue ArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles

Research Article
Online Published: 14 May 2024


Preparation and Evaluation of Mucoadhesive Film Containing Alcoholic Extracts Of Fruits of Coccina grandis and Rhizomes of Glycyrrhiza glabra for Treating Mouth Ulcers

Chhaya Harihar Gadgoli, Anant Pai, Rohan Parab, Sahil Rahane, Mayuresh Bhamode, Uday Sonone, Manasi Chogale.


Abstract
Background and Aim: Fruits of Coccinia grandis and rhizomes of Glycyrrhiza glabra are reported to have utility in treatment of mouth ulcers and other ulcers. In mouth ulcers there is rupture of oral mucosal layer further this can lead to infections. The objective of the present study is to utilize the healing potentials of these two herbs and formulate mucoadhesive film which has added advantage of longer stay in oral cavity.
Methods: The extracts of C.grandis and G. glabra were standardized for the content of Lupeol and Glycyrrhetinic acid respectively. Mucoadhesive patch was prepared by casting film of Polyvinyl alcohol and Carbopol containing ethanolic extracts of fruits of C. grandis and rhizomes of G.glabra. The patch was evaluated for content of Glycyrrhetinic acid and Lupeol, folding endurance, moisture content. pH, mucoadhesive time, mucoadhesive strength and release profile.
Results: The standardized extracts were incorporated into mucoadhesive patch with the content of Lupeol and Glycyrrhetinic acid to be 0.548 mg and 0.507 mg respectively, in a patch size of 2 cm in diameter and weighing 18 mg. The release profile indicated release of 50% of Glycyrrhetinic acid while 70 % lupeol from the patch. Mucoadhesion time of about 180 minutes and mucoadhesive strength of 6.47 dyne/ cm2.
Conclusion: Mucoadhesive buccal patches containing alcoholic extracts of roots /rhizomes G.glabra and fruits of C. grandis could be successfully formulated.

Key words: Glycyrrhetinic acid, Lupeol, Glycyrrhiza glabra, Coccina grandis, Mouth Ulcers , Mucoadhesive Buccal Patches


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Chhaya Harihar Gadgoli
Articles by Anant Pai
Articles by Rohan Parab
Articles by Sahil Rahane
Articles by Mayuresh Bhamode
Articles by Uday Sonone
Articles by Manasi Chogale
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Gadgoli CH, Pai A, Parab R, Rahane S, Bhamode M, Sonone U, Chogale M. Preparation and Evaluation of Mucoadhesive Film Containing Alcoholic Extracts Of Fruits of Coccina grandis and Rhizomes of Glycyrrhiza glabra for Treating Mouth Ulcers. J Biol Res Rev. 2024; 1(2): 70-78. doi:10.5455/JBRR.20240420060410

Web Style

Gadgoli CH, Pai A, Parab R, Rahane S, Bhamode M, Sonone U, Chogale M. Preparation and Evaluation of Mucoadhesive Film Containing Alcoholic Extracts Of Fruits of Coccina grandis and Rhizomes of Glycyrrhiza glabra for Treating Mouth Ulcers. https://www.wisdomgale.com/jbrr/?mno=198430 [Access: January 22, 2025]. doi:10.5455/JBRR.20240420060410

AMA (American Medical Association) Style

Gadgoli CH, Pai A, Parab R, Rahane S, Bhamode M, Sonone U, Chogale M. Preparation and Evaluation of Mucoadhesive Film Containing Alcoholic Extracts Of Fruits of Coccina grandis and Rhizomes of Glycyrrhiza glabra for Treating Mouth Ulcers. J Biol Res Rev. 2024; 1(2): 70-78. doi:10.5455/JBRR.20240420060410


Vancouver/ICMJE Style

Gadgoli CH, Pai A, Parab R, Rahane S, Bhamode M, Sonone U, Chogale M. Preparation and Evaluation of Mucoadhesive Film Containing Alcoholic Extracts Of Fruits of Coccina grandis and Rhizomes of Glycyrrhiza glabra for Treating Mouth Ulcers. J Biol Res Rev. (2024), [cited January 22, 2025]; 1(2): 70-78. doi:10.5455/JBRR.20240420060410


Harvard Style

Gadgoli, C. H., Pai, . A., Parab, . R., Rahane, . S., Bhamode, . M., Sonone, . U. & Chogale, . M. (2024) Preparation and Evaluation of Mucoadhesive Film Containing Alcoholic Extracts Of Fruits of Coccina grandis and Rhizomes of Glycyrrhiza glabra for Treating Mouth Ulcers. J Biol Res Rev, 1 (2), 70-78. doi:10.5455/JBRR.20240420060410


Turabian Style

Gadgoli, Chhaya Harihar, Anant Pai, Rohan Parab, Sahil Rahane, Mayuresh Bhamode, Uday Sonone, and Manasi Chogale. 2024. Preparation and Evaluation of Mucoadhesive Film Containing Alcoholic Extracts Of Fruits of Coccina grandis and Rhizomes of Glycyrrhiza glabra for Treating Mouth Ulcers. Journal of Biological Research and Reviews, 1 (2), 70-78. doi:10.5455/JBRR.20240420060410


Chicago Style

Gadgoli, Chhaya Harihar, Anant Pai, Rohan Parab, Sahil Rahane, Mayuresh Bhamode, Uday Sonone, and Manasi Chogale. "Preparation and Evaluation of Mucoadhesive Film Containing Alcoholic Extracts Of Fruits of Coccina grandis and Rhizomes of Glycyrrhiza glabra for Treating Mouth Ulcers." Journal of Biological Research and Reviews 1 (2024), 70-78. doi:10.5455/JBRR.20240420060410


MLA (The Modern Language Association) Style

Gadgoli, Chhaya Harihar, Anant Pai, Rohan Parab, Sahil Rahane, Mayuresh Bhamode, Uday Sonone, and Manasi Chogale. "Preparation and Evaluation of Mucoadhesive Film Containing Alcoholic Extracts Of Fruits of Coccina grandis and Rhizomes of Glycyrrhiza glabra for Treating Mouth Ulcers." Journal of Biological Research and Reviews 1.2 (2024), 70-78. Print. doi:10.5455/JBRR.20240420060410


APA (American Psychological Association) Style

Gadgoli, C. H., Pai, . A., Parab, . R., Rahane, . S., Bhamode, . M., Sonone, . U. & Chogale, . M. (2024) Preparation and Evaluation of Mucoadhesive Film Containing Alcoholic Extracts Of Fruits of Coccina grandis and Rhizomes of Glycyrrhiza glabra for Treating Mouth Ulcers. Journal of Biological Research and Reviews, 1 (2), 70-78. doi:10.5455/JBRR.20240420060410


Author LoginReviewer LoginAbout PublisherOpen Access PolicyEditorial PoliciesEditorial Review PolicyPeer Review PolicyEditorial & Peer Review ProcessPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Privacy PolicyCorrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesDigital Archiving & Preservation PoliciesTerms of UseLicense InformationCopyright Information

About Journal of Biological Research and Reviews

Journal of Biological Research and Reviews is an international, peer-reviewed, open access journal, providing a platform for advances in basic, translatio ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information

Your comments are very important to us

We welcome your ideas, suggestions, comments, or questions. To reach Editorial Board please use one of the methods provided below.
 

Emails:

info@wisdomgale.com
editorinchief@ejmanager.com

Office Address:
WisdomGale Publishing
14 Rue de Grand-Bigard,
1082 Brussels
Belgium
 
We will respond within 48 to 72 hours.
 
Change of address or personal information? Please visit your account at www.ejmanager.com to update your information.